Amilin 25mg Tablet

✔️ Uses of Amilin 25

• Treatment of Depression
• Treatment of Migraine
• Neuropathic pain

✔️ How to use Amilin 25

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Amilin 25 may be taken with or without food, but it is better to take it at a fixed time.

✔️ How does Amilin 25 work?

Amilin 25 is a tricyclic antidepressant. It works by increasing the levels of chemical messengers in the brain that help in regulating mood and treat depression. It also stops the transmission of pain signals from nerves to the brain thereby relieving neuropathic pain (pain from damaged nerves).

✔️ Side effects of Amilin 25

• Weight gain
• Congested nose
• Dryness in mouth
• Aggressive behavior
• Agitation
• Confusion
• Tremors
• Speech disorder
• Palpitations
• Taste change
• Paresthesia (tingling or pricking sensation)
• Abnormality of voluntary movements
• Loss of accommodation
• Atrioventricular block
• Micturition disorders
• Erectile dysfunction
• Abnormal ECG
• The decreased sodium level in the blood
• Increased heart rate
• Irregular heartbeat
• Constipation
• Nausea
• Weight gain
• Difficulty in urination
• Slurred or slow speech
• Nasal congestion (stuffy nose)
• Orthostatic hypotension (sudden lowering of blood pressure on standing)

✔️ Quick Suggestions:

• Amilin 25 may take 4 to 6 weeks to begin functioning. Continue to take it as directed.
• It may induce drowsiness. Take it before night and avoid driving or doing anything that requires attention until you know how it affects you.
• When taking Amilin 25, avoid drinking alcohol since it may cause extreme tiredness.
• Keep an eye on your weight throughout treatment because this medication might induce weight gain and an increase in hunger.
• It may produce a sharp reduction in blood pressure. If you've been sitting or lying down, get up carefully.
• Consult your doctor if you experience unexpected mood swings or suicidal thoughts.
• Exercising aids the body's natural antidepressant synthesis. It also helps to relieve stress, improve mood, and promote self-esteem.
• Avoid smoking and alcohol consumption.
• Learn about your condition, understand the risk factors, and follow the doctor’s treatment plan.

✔️ Indications of Amilin 25

Amilin 25 is used to treat mental/emotional issues including depression. It may help you boost your mood and sense of well-being, decrease worry and stress, sleep better, and have more energy. This drug belongs to the tricyclic antidepressant family of pharmaceuticals. It works by changing the balance of certain natural chemicals in the brain (neurotransmitters like serotonin).

✔️ Pharmacology

The mechanism of action of this drug is not fully understood. Amitriptyline is thought to inhibit the membrane pump mechanism, which allows transmitter amines such as norepinephrine and serotonin to re-enter the brain, thereby increasing their concentration in synaptic clefts. These amines are essential for mood regulation. One of the oldest theories about depression is that depression is caused by a lack of serotonin (5-HT) and/or norepinephrine (NE) neurotransmission in the brain.

✔️ Dosage & Administration of Amilin 25

Depression: 

• 75 mg (Elderly and Adolescents 30-75 mg) daily in divided doses or as a single dose at bedtime, gradually increased to 150-200 mg as needed;
• Children under the age of 16 are not recommended for depression.

Nocturnal Enuresis: 

• 10-20 mg for children aged 7 to 10, 25-50 mg

For Children aged 11 to 16:

• With a maximum dose of 100 mg. Treatment period (including gradual withdrawal) 3 months-full physical examination before the next course

Migraine Prophylaxis: 100 mg daily.

• 10-25 mg three times per day for Tension Headaches.

✔️ Interaction

Alcohol and opioid analgesics have a stronger sedative impact when combined with TCA. TCA raises the risk of ventricular arrhythmias when used with Moxifloxacin or Terfenadine. Amitriptyline metabolism is inhibited by Disulfiram and Cimetidine. TCA increases the risk of postural hypotension when used with diuretics.

✔️ Contraindications

Myocardial infarction, arrhythmias, especially heart block of any degree, mania, and severe liver illness are all contraindications to taking amitriptyline. Sedation might impair one's ability to drive or operate machines at first.

✔️ Pregnancy & Lactation

• Pregnancy Classification C. It has been proven that amitriptyline crosses the placenta. During pregnancy, amitriptyline should only be taken if the possible benefit to the mother outweighs the danger to the fetus.
• Amitriptyline is passed through the breast milk. Because Amitriptyline has the potential to produce significant adverse effects in nursing infants, a choice should be taken whether to stop breastfeeding or stop taking the medicine, taking into consideration the drug's value to the mother.

✔️ Precautions & Warnings

• In individuals with a history of epilepsy, glaucoma, urinary retention, heart illness, diabetes, pregnancy, hepatic impairment, thyroid disease, elevated intra-ocular pressure, or psychoses, it should be taken with caution (may aggravate mania).
• Amilin 25 may take 4 to 6 weeks to begin working. Continue to take it as directed.
• It may cause drowsiness. Take it before bedtime and avoid driving or doing anything that requires concentration until you know how it affects you.
• When taking Amilin 25, avoid drinking alcohol as it may cause excessive sleepiness.
• Keep an eye on your weight during treatment because this medication can cause weight gain and an increase in appetite.
• It may cause a sharp drop in blood pressure. If you've been sitting or lying down, get up slowly.
• Consult your doctor if you experience sudden mood swings or suicidal thoughts.

✔️ Storage Conditions

Store below 30°C in a cool, dry location. Light and dampness should be avoided.